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rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Among individuals of African or Hispanic/Latino ancestry enrolled in 2 academic medical center-based biobanks, the TTR V122I genetic variant was significantly associated with heart failure.
|
31821430 |
2019 |
|
rs9909004
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recently discovered cardiac-specific regulatory variant for PRKCA (rs9909004) was independently associated with a decreased risk for all-cause mortality in patients with HF.
|
31728800 |
2019 |
|
rs9303504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox proportional hazards models adjusted for established clinical risk factors and genomic ancestry tested the independent association of rs9909004 or rs9303504 and the variant interactions with cornerstone HF pharmacotherapies (beta-blockers or angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) in additive genetic models.
|
31728800 |
2019 |
|
rs140226130
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These included signs related to both ATTRm and ATTRwt such as chronic ischaemic heart disease (rs140226130, p = 2.00 × 10<sup>-6</sup>), heart failure (rs73956431, p = 2.74 × 10<sup>-6</sup>), atrial fibrillation (rs10163755, p = 4.63 × 10<sup>-6</sup>), dysphagia (rs2949506, p = 3.95 × 10<sup>-6</sup>), intestine diseases (rs970866, p = 7.14 × 10<sup>-6</sup>) and anxiety (rs554521234, p = 8.85 × 10<sup>-6</sup>).
|
31659433 |
2019 |
|
rs73956431
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These included signs related to both ATTRm and ATTRwt such as chronic ischaemic heart disease (rs140226130, p = 2.00 × 10<sup>-6</sup>), heart failure (rs73956431, p = 2.74 × 10<sup>-6</sup>), atrial fibrillation (rs10163755, p = 4.63 × 10<sup>-6</sup>), dysphagia (rs2949506, p = 3.95 × 10<sup>-6</sup>), intestine diseases (rs970866, p = 7.14 × 10<sup>-6</sup>) and anxiety (rs554521234, p = 8.85 × 10<sup>-6</sup>).
|
31659433 |
2019 |
|
rs548787835
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At 6 months of age when congestive heart failure is apparent in R120G mice, both LC3-II flux and TFEB activities were severely suppressed, while mTORC1 activity increased.
|
31297061 |
2019 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, carriers of at least one variant <i>GSTP1</i>∗Val (rs1695) allele were at 1.7-fold increased HF risk than <i>GSTP1</i>∗Ile/Ile carriers (<i>p</i> = 0.031), which was higher when combined with the variant <i>GSTA1</i>∗B allele (OR = 2.2, <i>p</i> = 0.034).
|
31275451 |
2019 |
|
rs1801282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study did not reveal any correlation between the <i>PPARG2</i> Pro12Ala and <i>TNFα</i> -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.
|
31275366 |
2019 |
|
rs1805192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study did not reveal any correlation between the <i>PPARG2</i> Pro12Ala and <i>TNFα</i> -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.
|
31275366 |
2019 |
|
rs10189761
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs10189761 and rs737337 were identified, for the first time, as independent predictors of major clinical outcomes in patients with HF.
|
31209632 |
2019 |
|
rs10423928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs1800437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs737337
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs10189761 and rs737337 were identified, for the first time, as independent predictors of major clinical outcomes in patients with HF.
|
31209632 |
2019 |
|
rs9351814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs3212247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, participants carrying the rs3212247 CC genotype had higher plasma levels of RIP3 than those carrying the TT or TC genotype (p for trend = 0.02) in New York Heart Association class III HF group.
|
31148336 |
2019 |
|
rs3212254
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was found between the RIP3 missense variant rs3212254 and risk or prognosis of HF after adjustment for traditional risk factors.
|
31148336 |
2019 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity.
|
30978507 |
2019 |
|
rs2230345
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity.
|
30978507 |
2019 |
|
rs4149056
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with OATP1B1 521T>C mutant-type carrier had slightly higher trough SDC (0.98 ± 0.53 ng/mL) than those with wild-type carrier (0.74 ± 0.40 ng/mL) when they have repaired renal function.Heart failure patients with severe renal dysfunction (GFR<60 mL/min) and/or OATP1B1 521T>C mutant-type carriers are recommended a smaller dosage of digoxin and strict therapeutic drug monitoring.
|
30946364 |
2019 |
|
rs7311358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Blood samples were collected for the analysis of trough SDC (immunofluorescence) and the polymorphisms of OATP1B1 388A>G, OATP1B1 521T>C, and OATP1B3 699G>A (PCR-RFLP and Sanger sequencing).Patients with glomerular filtration rate (GFR) under 30 mL/min had significantly higher trough SDC (1.20 ± 0.50 ng/mL) than recommended trough SDC for heart failure patients.
|
30946364 |
2019 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure.
|
30756358 |
2019 |
|
rs1801252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure.
|
30756358 |
2019 |
|
rs1136201
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This review found that HER2 rs1136201 can have the potential in predicting trastuzumab-related heart failure.
|
30594345 |
2019 |
|
rs1799998
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Overall, our meta-analysis suggested that rs1799998 polymorphism may serve as a potential biological marker of AF in East Asians and subjects with EH or HF.
|
30529851 |
2020 |
|
rs200432861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The compound heterozygous variants c.7994T>C, p.(Leu2665Pro) and c.8518C>T, p.(Arg2840Cys) in PKHD1 were identified in a Chinese family with CHF by whole-exome sequencing.
|
30507656 |
2019 |